SKU: 63485519679

CCL17/TARC Protein, Mouse

Sale price$104.40 Regular price$116.00
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Description

CCL17/TARC Protein, MouseProduct Specification Species Mouse Amino Acid Sequence ARATNVGREC CLDYFKGAIP IRKLVSWYKT SVECSRDAIV FLTVQGKLIC ADPKDKHVKK AIRLVKNPRP Expression System E. coli Molecular Weight 7. 9 kDa Purity > 97 % by SDS PAGE & HPLC Endotoxin <1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, pH 7. 4. Reconstitution Recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.

Product Specification


Species Mouse
Amino Acid Sequence

ARATNVGREC CLDYFKGAIP IRKLVSWYKT SVECSRDAIV FLTVQGKLIC ADPKDKHVKK AIRLVKNPRP

Expression System E.coli
Molecular Weight

7.9 kDa

Purity > 97 % by SDS-PAGE & HPLC
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH 7.4.
Reconstitution

Recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
3 months, -20 to -70 °C under sterile conditions after reconstitution.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
Avoid repeated freeze-thaw cycles.

Background

CCL17 also known as TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine and SCYA17, is encoded by the CCL17 gene located on the chromosome 8. Among CC chemokine family members, CCL17 has approximately 24 – 29 % amino acid sequence identity with RANTES, MIP-1α, MIP-1β, MCP-1, MCP-2, MCP-3 and I-309. CCL17 is a secreted protein and expressed by thymus cells constitutively and phytohemagglutinin-stimulated peripheral blood mononuclear cells transiently. It signals through the chemokine receptors CCR4 and CCR8 and displays chemotactic activity for T lymphocytes and some other leukocytes. CCL17 play an important role in skin diseases such as atopic dermatitis, bullous pemphigoid and mycosis fungoides. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils.

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Exchange/Return Notes
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SKU: 63485519679

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