SKU: 33126682447

BRF 45™

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Description

BRF 45™Productinformatie Designs for Health BRF 45 is een geavanceerde vitamine K formule ter ondersteuning van de botgezondheid. Het supplement bevat een klinisch relevante dosering van vitamine K2 (als MK 4), aangevuld met vitamine K1 en GG Gold (geranylgeraniol). Deze combinatie is ontwikkeld om botremodelleringsprocessen (Bone Remodeling Factors, BRF) te ondersteunen bij zowel vrouwen als mannen. Wat is BRF 45? BRF 45 is een hooggedoseerde vitamine K

Productinformatie

Designs for Health BRF 45™ is een geavanceerde vitamine K-formule ter ondersteuning van de botgezondheid. Het supplement bevat een klinisch relevante dosering van vitamine K2 (als MK-4), aangevuld met vitamine K1 en GG-Gold® (geranylgeraniol). Deze combinatie is ontwikkeld om botremodelleringsprocessen (Bone Remodeling Factors, BRF) te ondersteunen bij zowel vrouwen als mannen.

Wat is BRF 45™?

BRF 45™ is een hooggedoseerde vitamine K-formule die zich richt op het behoud van sterke botten en een gezonde vaatstructuur. De formule is specifiek samengesteld om leeftijds- en hormoongerelateerde veranderingen in de botstofwisseling te ondersteunen, zoals tijdens de menopauze en andropauze.

Wat doet vitamine K2 (MK-4)?

Vitamine K2 in de vorm van menaquinon-4 (MK-4) speelt een rol bij het activeren van eiwitten die betrokken zijn bij het botmetabolisme en de calciumhuishouding. MK-4 wordt vaak toegepast in hogere doseringen vanwege de specifieke rol bij botremodellering en vaatgezondheid.

Wat is GG-Gold® (geranylgeraniol)?

GG-Gold® is een natuurlijk extract uit annattozaad (Bixa orellana) en levert trans-geranylgeraniol, een stof die betrokken is bij de endogene aanmaak en omzetting van vitamine K-verbindingen. Het wordt toegevoegd ter ondersteuning van de werking van vitamine K in het lichaam.

Voordelen van BRF 45™

De onderstaande gezondheidsclaims zijn in afwachting van goedkeuring door de EFSA.

BRF 45™ kan bijdragen aan:

  • Ondersteuning van normale botgezondheid en botsterkte*
  • Het behoud van een gezonde calcium- en collageenbalans in botten*
  • Ondersteuning van botremodelleringsprocessen*
  • Behoud van arteriële elasticiteit en vaatintegriteit*
  • Extra ondersteuning bij een verhoogde behoefte aan vitamine K, bijvoorbeeld bij gebruik van bepaalde medicatie*

*Gezondheidsclaims in afwachting van goedkeuring door de Europese Commissie

Waarom kiezen voor Designs for Health BRF 45™?

✔ Bevat 45 mg vitamine K2 (MK-4) – klinisch relevante dosering
✔ Met vitamine K1 (1000 mcg) voor aanvullende ondersteuning
✔ Met GG-Gold® uit annattozaad
✔ Gericht op botgezondheid én vaatgezondheid
✔ Vrij van gluten, zuivel en soja
✔ Non-GMO
✔ Professionele kwaliteit van Designs for Health

Samenstelling per dagdosering (2 softgels)

Ingrediënt Hoeveelheid % RI
Vitamine K1 (fytonadion) 1000 mcg 1333 %
Vitamine K2 (menaquinon-4, MK-4) 45 mg
Trans-geranylgeraniol (GG-Gold® uit annattozaad) 30 mg

✝ RI niet vastgesteld

Overige ingrediënten:
Medium chain triglycerides (MCT), rundergelatine, glycerine, gezuiverd water.

Vrij van

✗ Gluten
✗ Zuivel
✗ Soja
✗ GMO’s

Gebruik en dosering

Neem 2 softgels per dag bij een maaltijd.
Gespreide inname over de dag wordt aanbevolen.

Waarschuwing

Raadpleeg vóór gebruik een deskundige bij gebruik van antistollingsmedicatie zoals warfarine of coumadine.
Een voedingssupplement is geen vervanging voor een gevarieerde voeding en gezonde leefstijl.

Veelgestelde vragen

Voor wie is BRF 45™ geschikt?

BRF 45™ is geschikt voor volwassenen die hun botgezondheid en vaatfunctie willen ondersteunen, met name bij veroudering of hormonale veranderingen.

Waarom bevat dit supplement zowel vitamine K1 als K2?

Vitamine K1 en K2 hebben verschillende functies binnen het lichaam. De combinatie ondersteunt zowel de algemene vitamine K-status als specifieke bot- en vaatprocessen.

Is BRF 45™ geschikt bij medicijngebruik?

Bij gebruik van bloedverdunners dient altijd eerst overleg plaats te vinden met een zorgprofessional.

Inhoud: 60 softgels
Merk: Designs for Health
Herkomst: Verenigde Staten

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SKU: 33126682447

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4.4 ★★★★★
Based on 1714 reviews
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Product Reviews
C
Verified Purchase
Cakirsch
Chelsea, US
★★★★★ 4
Puppy loves it. Well built and fun for her to play with.
Size: 15 in, Color: Retriever
My double doodle mix loved this toy. It is well made and she loves the different texture of the rope. Sadly she has already torn the rope apart and so now it’s just the leather part. This would be the perfect toy for non agressive chewers. Wish the rope lasted a little longer. SPOT is my new favorite company to get her chew toys from now. They’re well built and aren’t expensive like all the other dog toys out there.
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Reviewed in the United States on June 30, 2025
K
Verified Purchase
KAV
Battle Creek, US
★★★★★ 2
Destroyed in under 10 minutes
Size: 9 in, Color: Large Bone
I bought 2 of these toys, one for my 9 year old great dane who isn't an aggressive chewer, and one for my 6 month old puppy who is average. In less than 10 minutes both were destroyed and my dane managed to swallow a good chunk. I wasn't surprised when they both had small holes on the ends and started pulling the stuffing out. The stuffing and squeakers were confiscated immediately, but I let them keep chewing. By the time I came back from throwing the insides away, both dogs had chewed the toys in half and my dane swallowed a chunk when he saw me coming. The puppy was going to do the same thing, but luckily we're working on his "drop" command so he was excited enough for the bigger payout and dropped it. They didn't just come apart at the seams, the whole toy ripped in half making it too easy to swallow. Neither of them are aggressive cheers and the toys didn't hold up at all. A stuffed animal toy would have lasted longer (and has any time I've allowed it). 10 minutes of playtime is probably too generous , but I'm trying to be fair. If I hadn't been right there watching them, they both would have been able to swallow the whole thing in minutes. Definitely not safe for any amount of actual chewing.
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Reviewed in the United States on November 14, 2025
S
Verified Purchase
Skylaire
Cuba, US
★★★★★ 5
The perfect teething toy for a puppy of any size - apparently indestructible!
Size: 9 in, Color: Large Bone, Size: 9 in, Color: Large Bone
I ordered this product for an overly excitable, destructive corgi chihuahua mix puppy, who was teething. He was a foster and managed to destroy, almost immediately, every toy I had on-hand for him, and toys I picked up at the local pet store. I was very concerned he'd swallow parts of toys, which can lead to fatal intestinal blockages, not to mention extremely high vet bills which I couldn't cover as a simple foster mom. When it arrived, I crossed my fingers that the "Seam Protection - doubled-stitched seams with heavy duty thread" would actually add "extra durability." And I was NOT disappointed! The bone shape of the toy would probably fit comfortably in the mouth of any dog or puppy, as you can see from photo #4. What's coolest about the shape of this toy is the pup can sink all of his or her teeth into it, providing comfort for the entire mouth and not just a few teeth or only one section of its mouth at a time. I was much more experienced as a kitten foster mom, and had had similar difficulties finding teething toys for kittens. This toy is thin and light weight enough that I imagine it could provide relief for little kitten mouths, also, but I didn't get to find out, as my little foster pup chose this as his #1 favorite toy and brought it with him to his forever home. I wanted to know how long it would take before he'd destroy it, though (picture 5 he'd had this Dura-Fused bone toy for a few hours short of one week, and the last photo - you'll see he'd not even undone a small portion of the seam!) Overall I would highly recommend this product for teething babies of almost any species. As far as I could tell it is indestructible. Almost seven days of constant gnawing and he'd not even taken one stitch out, created any tear or rip, let alone, gotten close to being able to swallow the squeaker (always a fear!). I imagine months later, he's still been unsuccessful at ripping/tearing this toy at all. I'd gladly buy again should I foster any dog or puppy - the company lives up to its moniker, Ethical Products, because they've produced a no-frills and apparently indestructible squeak toy which I'd have no fears of leaving with a teething puppy unsupervised. Highly recommended!
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Reviewed in the United States on November 28, 2020
A
Verified Purchase
Amazon Customer
Battle Creek, US
★★★★★ 3
Good tug toy
Size: 15 in, Color: Retriever
I have a doberman that shready everything in 2.5 seconds. This lasted a few days so was impressed for the cost. Would buy again as he really liked it.
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Reviewed in the United States on December 28, 2025
L
Verified Purchase
Larry B.
Omaha, US
★★★★★ 5
My dog’s new favorite
Size: 8 in, Color: Squirrel
didn’t expect much for the price but my dog actually loves this thing. It’s tough enough to hold up to regular chewing and the leather gives it a nice texture that’s different from the usual plush toys. He carries it around like it’s his prize. It’s not indestructible and if your dog is a heavy shredder it probably won’t last forever but for moderate chewers it holds up way better than a lot of toys I’ve tried. Definitely worth grabbing again.
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Reviewed in the United States on July 19, 2025

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