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Description
S-RMab® ATRX Recombinant Rabbit mAb,PBS Only (SDT-458-37)Product Specification Host Rabbit Antigen ATRX Synonyms ATP dependent helicase ATRX, X linked helicase II, X linked nuclear protein (XNP), Znf HX, RAD54L, XH2 Immunogen Recombinant Protein Location Nucleus Accession P46100 Clone Number SDT 458 37 Antibody Type Recombinant mAb Application IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12
Product Specification
| Host | Rabbit |
| Antigen | ATRX |
| Synonyms | ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein (XNP), Znf-HX, RAD54L, XH2 |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | P46100 |
| Clone Number | SDT-458-37 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:250 |
Background
ATRX is encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The ATRX gene is frequently mutated in a variety of tumors, including adult lower-grade gliomas, pediatric glioblastoma multiforme, pediatric adrenocortical carcinoma, osteosarcoma, and neuroblastoma. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis.
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