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Description
CD79B His Tag Protein, HumanProduct Specification Species Human Synonyms CD79b; B29; IGB; Ig beta Accession P40259 Amino Acid Sequence Ala29 Asp159, with C terminal His Expression System HEK293 Molecular Weight 26 35kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | CD79b; B29; IGB; Ig-beta |
| Accession | P40259 |
| Amino Acid Sequence | Ala29-Asp159, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 26-35kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Venkitaraman, A. R., G. T. Williams, P. Dariavach, and M. S. Neuberger. 1991. The B-cell antigen receptor of the five immunoglobulin classes. Nature 352:777. 7. Campbell, K. S., E. J. Hager, R. J. Friedrich, and J. C. Cambier. 1991. IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc. Natl. Acad. Sci. USA 88:3982. Kim, K. M., G. Alber, P. Weiser, and M. Reth. 1993. Signalling function of the B-cell antigen receptors. Immunol. Rev. 132:125. Radaev, S, et al. (2010) Structure 18:934. |
Background
CD79B encodes CD79b (also known as Igβ) belonging to the Ig superfamily, a transmembrane protein that associate with CD79a(Ig-α) via a disulfide bond. CD79a and CD79b encoded by the mb-1 and B29 genes, respectively. CD79A and CD79B are proximal B-cell receptor subunits that contain an immunoreceptor tyrosine-based activation motif (ITAM) that frequently harbors somatic mutations. Ig-α and Ig-β form a disulfide-linked heterodimer that associates with membrane-bound Ig (mIg)3 molecules of every Ig class to form the B cell Ag receptor (BCR) complex. The variable region of the H and L (IgH and IgL) chains of the mIg molecules constitute the Ag-binding portion of the BCR, whereas the Ig-α/Ig-β heterodimer is its signaling component. CD79b is ubiquitously expressed on the surface of mature B-cell lymphomas, including DLBCL.
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