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Description
IL-18Rα/IL-1R5 His Tag Protein, HumanProduct Specification Species Human Synonyms CD218a, CD218a, CDw218a, IL18R1, IL18RA, IL 18Ralpha, IL 18R alpha, IL18Ralpha2, IL1RRP, IL 1Rrp, Interleukin 18 receptor 1, IL 1 R5, IL 1 Rrp, IL 18 R alpha, IL 18 R1, IL18R alpha, IL18R1, IL 18Ra Accession Q13478 Amino Acid Sequence Cys22 Arg329, with C terminal His Expression System HEK293 Molecular Weight 53 72kDa (Reducing) Purity 95% by SDS PAGE &95% by SEC HPLC Endotoxin <0. 1EU g Conjugation
Product Specification
| Species | Human |
| Synonyms | CD218a, CD218a, CDw218a, IL18R1, IL18RA, IL-18Ralpha, IL-18R-alpha, IL18Ralpha2, IL1RRP, IL-1Rrp, Interleukin-18 receptor 1, IL-1 R5, IL-1 Rrp, IL-18 R alpha, IL-18 R1, IL18R alpha, IL18R1, IL-18Ra |
| Accession | Q13478 |
| Amino Acid Sequence | Cys22-Arg329, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 53-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &＞95% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967. |
Background
Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta. Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either. independently of SLC12A3, or as a complex with SLC12A3.
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4.5 ★★★★★
Based on 1292 reviews
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Product Reviews
★★★★★ 5
An amazing, if sometimes dark, memoir of work, solitude, and taking a pragmatic path in life.
Format: Hardcover
What do you do, when your only viable financial prospects are to move to even more remote, cold, dark and desolate land where you are part of a corporate mining operation dredging sands for valuable resources, living onsite in a company owned dormitory? Beaton recalls all this in her memoir of her post-university time, where she was faced with this decision to either live and work the oil sands, or face a life of financial bondage trying to pay back student loans, a decision we see many of her own countrymen face as their only viable means to survive.
If you are familiar with Beaton's comic strip work, you'll see familiar reference to the genesis of it here, but Ducks is a far more serious graphic novel. Both engaging and often times bleak, Ducks gives a wonderful window into the reality of Canada's oil industry, and the humanity of the people, who are nothing more than cogs in a machine, that run it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 7, 2023
★★★★★ 5
What is NOT to love about Lynda Barry?
Format: Paperback
I’ve been reading Lynda Barry since the 80s and am currently at work on a graphic novel, that I’m writing and illustrating. I have always believed in learning from the best and Barry has always been a favorite, from the creativity, recall and connections she makes with her work as well as with me (and I assume her other readers as well). This book delves into the connections of words and images, how to conjure and connect, especially with the whole creative vibe. She works with young people and the pipeline to that cerebral communication is appreciated and thought provoking as well, as my work will be geared to a younger audience. This is for anyone who interested in the process of sequential art, creating comics, characters, connecting with creative elements, it’s also a visually stunning book (again, the nerd in me, loved all the cross-references with the visual and other, using calligraphic and other historic, formal art elements along with the more personal character, visual creations and exercises. Thought-provoking and image inducing, indeed!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 2, 2020
★★★★★ 5
Lynda Barry is Awesome
Format: Kindle
This book is fantastic if you want to make comics by yourself or with a classroom. Barry packs in loads of experience teaching and making art. Her style of drawing is simple and straight forward. She uses a great method that empowers the reader to make art and share it.
I want to be half the teacher Barry is.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 1, 2024
★★★★★ 5
Creative outlets!
Format: Paperback
I LOVE following the activities in this book. Perfect for anyone who wants to draw but thinks they can’t, great exercises and fun for those creative blocks when you want to be creative but just can’t get it flowing.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2025
★★★★★ 5
This! Book! Rocks!
Format: Paperback
If you enjoy laughing, having fun with your friends and family, and doing cool stuff, you will love Lynda Barry's Making Comics. This is a thoughtful and complete recap of her live class at the University of Wisconsin, includes much of her substantial thought and philosophy on the role of image making in human evolution, and is full of her (and her students') amazing artwork; but it's also full of excessively FUN drawing exercises that are wonderful for sucky drawers as well as professional artists. We dig this book so bad!!! Best gift I've given myself in a million years!!!!!!!!!!!! Maybe I had a little bit forgotten how much I! Love! Lynda! Barry!!!!! So if you wish you could go move to Wisconsin and take her class like I do, instead just save the planet the extra greenhouse gases and get this book instead and do the class at your kitchen table with your friends!!! Maybe also order it from your local groovy independent bookstore so you can stick it to the man!!!
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Reviewed in the United States on January 2, 2020
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