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Description
Fas Ligand/TNFSF6 His Tag Protein, MouseProduct Specification Species Mouse Synonyms CD95LFas ligandSPAFASLGSoluble Fas ligandsFasLReceptor binding FasL ectodomainFasL ICDTNFSF6Apoptosis antigen ligandTumor necrosis factor ligand superfamily member 6APLCD178Fas Ligand (TNF Superfamily Member 6)Fas Antigen LigandCD95 LigandCD95 LAPTLMutant Tumor Necrosis Factor Family Member 6Apoptosis (APO 1) Antigen Ligand 1CD178 AntigenALPS1BTNLG1AFasLFas Ligand ProteinSPPL2A processed FasL
Product Specification
| Species | Mouse |
| Synonyms | CD95L，Fas ligand，SPA，FASLG，Soluble Fas ligand，sFasL，Receptor-binding FasL ectodomain，FasL ICD，TNFSF6，Apoptosis antigen ligand，Tumor necrosis factor ligand superfamily member 6，APL，CD178，Fas Ligand (TNF Superfamily， Member 6)，Fas Antigen Ligand，CD95 Ligand，CD95-L，APTL，Mutant Tumor Necrosis Factor Family Member 6，Apoptosis (APO-1) Antigen Ligand 1，CD178 Antigen，ALPS1B，TNLG1A，FasL，Fas Ligand Protein，SPPL2A-processed FasL form，APT1LG1，Tumor Necrosis Factor (Ligand) Superfamily， Member 6，Tumor Necros，TNFSF6 |
| Accession | P41047-1 |
| Amino Acid Sequence | Pro132-Leu279, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 25-33kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review Cell Death Differ . 2012 Jan;19(1):42-50. Epub 2011 Sep 30. |
Background
Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigen-stimulated T cells. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include: T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
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4.4 ★★★★★
Based on 575 reviews
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Product Reviews
★★★★★ 5
An amazing, if sometimes dark, memoir of work, solitude, and taking a pragmatic path in life.
Format: Hardcover
What do you do, when your only viable financial prospects are to move to even more remote, cold, dark and desolate land where you are part of a corporate mining operation dredging sands for valuable resources, living onsite in a company owned dormitory? Beaton recalls all this in her memoir of her post-university time, where she was faced with this decision to either live and work the oil sands, or face a life of financial bondage trying to pay back student loans, a decision we see many of her own countrymen face as their only viable means to survive.
If you are familiar with Beaton's comic strip work, you'll see familiar reference to the genesis of it here, but Ducks is a far more serious graphic novel. Both engaging and often times bleak, Ducks gives a wonderful window into the reality of Canada's oil industry, and the humanity of the people, who are nothing more than cogs in a machine, that run it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 7, 2023
★★★★★ 5
What is NOT to love about Lynda Barry?
Format: Paperback
I’ve been reading Lynda Barry since the 80s and am currently at work on a graphic novel, that I’m writing and illustrating. I have always believed in learning from the best and Barry has always been a favorite, from the creativity, recall and connections she makes with her work as well as with me (and I assume her other readers as well). This book delves into the connections of words and images, how to conjure and connect, especially with the whole creative vibe. She works with young people and the pipeline to that cerebral communication is appreciated and thought provoking as well, as my work will be geared to a younger audience. This is for anyone who interested in the process of sequential art, creating comics, characters, connecting with creative elements, it’s also a visually stunning book (again, the nerd in me, loved all the cross-references with the visual and other, using calligraphic and other historic, formal art elements along with the more personal character, visual creations and exercises. Thought-provoking and image inducing, indeed!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 2, 2020
★★★★★ 5
Lynda Barry is Awesome
Format: Kindle
This book is fantastic if you want to make comics by yourself or with a classroom. Barry packs in loads of experience teaching and making art. Her style of drawing is simple and straight forward. She uses a great method that empowers the reader to make art and share it.
I want to be half the teacher Barry is.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 1, 2024
★★★★★ 5
Creative outlets!
Format: Paperback
I LOVE following the activities in this book. Perfect for anyone who wants to draw but thinks they can’t, great exercises and fun for those creative blocks when you want to be creative but just can’t get it flowing.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2025
★★★★★ 5
This! Book! Rocks!
Format: Paperback
If you enjoy laughing, having fun with your friends and family, and doing cool stuff, you will love Lynda Barry's Making Comics. This is a thoughtful and complete recap of her live class at the University of Wisconsin, includes much of her substantial thought and philosophy on the role of image making in human evolution, and is full of her (and her students') amazing artwork; but it's also full of excessively FUN drawing exercises that are wonderful for sucky drawers as well as professional artists. We dig this book so bad!!! Best gift I've given myself in a million years!!!!!!!!!!!! Maybe I had a little bit forgotten how much I! Love! Lynda! Barry!!!!! So if you wish you could go move to Wisconsin and take her class like I do, instead just save the planet the extra greenhouse gases and get this book instead and do the class at your kitchen table with your friends!!! Maybe also order it from your local groovy independent bookstore so you can stick it to the man!!!
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Reviewed in the United States on January 2, 2020
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