SKU: 20307848536

Phospho-PDGF Receptor α (Tyr1018) Recombinant Rabbit mAb (S-3482-7)

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Description

Phospho-PDGF Receptor α (Tyr1018) Recombinant Rabbit mAb (S-3482-7)Product Specification Host Rabbit Antigen Phospho PDGF Receptor (Tyr1018) Synonyms Platelet derived growth factor receptor alpha; PDGF R alpha; PDGFR alpha; Alpha platelet derived growth factor receptor; Alpha type platelet derived growth factor receptor; CD140 antigen like family member A; CD140a antigen; Platelet derived growth factor alpha receptor; Platelet derived growth factor receptor 2 (PDGFR 2); CD140a; PDGFR2; RHEPDGFRA; PDGFRA Immunogen

Product Specification


Host Rabbit
Antigen Phospho-PDGF Receptor α (Tyr1018)
Synonyms Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2 (PDGFR-2); CD140a; PDGFR2; RHEPDGFRA; PDGFRA
Immunogen Synthetic Peptide
Location Cell membrane
Accession P16234
Clone Number S-3482-7
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Ms
Positive Sample NIH/3T3 (starved overnight, then treated with 100 ng/ml PDGF for 5 minutes)
Predicted Reactivity Hu, Rt, Ck, Xe
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Ms

Background

Phospho-PDGF Receptor α (Tyr1018) is the activated form of the platelet-derived growth factor receptor alpha (PDGFRα) following phosphorylation at tyrosine residue 1018, representing the activation state of this receptor tyrosine kinase signaling pathway. This site is located within the kinase insert region of PDGFRα. Upon ligand binding (such as PDGF-AA, PDGF-BB, or PDGF-CC), the receptor undergoes dimerization and autophosphorylation, with phosphorylation at Tyr1018 providing a critical docking site for the signaling adaptors Grb2 and Shc, thereby activating the Ras-MAPK pathway to regulate cell proliferation, survival, and migration. Studies have shown that aberrant phosphorylation at Tyr1018 is closely associated with sustained activation of PDGFRα in conditions such as idiopathic pulmonary fibrosis, atherosclerosis, and various tumors (e.g., glioblastoma, gastrointestinal stromal tumors).

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SKU: 20307848536

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Mack L.
San Leandro, US
★★★★★ 5
Comfortable and easy to set up
Color: Black, Color: Black
I’m happy with this chair. It was not hard to assemble, and it feels stable after putting everything together. The mesh back is comfortable and breathable, so it doesn’t feel too hot when sitting for a while. The seat cushion is also thicker than I expected and feels soft enough for daily use. I like the adjustable headrest and the back support, especially for working at a desk. The chair looks simple and clean, and the wheels move smoothly. Good value for a home office chair.
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Reviewed in the United States on May 1, 2026
W
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Wen Cortes
Chelsea, US
★★★★★ 5
Exactly the Desk Chair I Was Looking For
Color: Black
had been needing a new desk chair for a while, and this one has been a great addition to my workspace. I use it every day while working, and it feels very comfortable, even when sitting for long periods of time. The seat provides good support, and the backrest helps me stay comfortable throughout the day. Assembly was straightforward, and the instructions were easy to follow. I also like how well it fits in my workspace and how nice it looks. So far, I am very happy with the comfort and overall quality. It has definitely made my workdays more enjoyable.
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Reviewed in the United States on June 8, 2026
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Turkey
Omaha, US
★★★★★ 4
very ergonomic
Color: Deep Black, Color: Deep Black
I bought this as a replacement for one of those gaming chairs that kills your back with a little lumbar pillow and this one is muuuuch better. the back support is everything you’d need and got rid of my neck pain after long periods of sitting and the seat cushion is supportive but still comfortable. It’s the kind of chair that you don’t really think about much because it’s so natural to sit in that you forget it’s there. The armrests flipping is a really nice feature too. One star off only because the head rest is so far back that i can’t really rest my head on it and every part of the chair that’s cloth is made of the same mesh texture like the armrests and seat. but i have no other complaints this is a good chair
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Reviewed in the United States on March 14, 2026
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Elva
Phoenix, US
★★★★★ 5
Comfortable Ergonomic Chair for Long Workdays
Color: Black, Color: Black
I’ve been using this chair for my home office, and it’s been a great addition to my workspace. The seat cushion is thick and comfortable, even after several hours of sitting, and the mesh back keeps good airflow throughout the day. I especially like the adjustable headrest, which provides extra neck support when leaning back during breaks. Assembly was straightforward, the chair feels sturdy, and the wheels roll smoothly on my floor. The all-black design also gives it a professional look that fits well in any office setup. Overall, it’s a comfortable and affordable ergonomic chair that offers excellent value for the price.
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Reviewed in the United States on May 28, 2026
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Emily Hopman
Phoenix, US
★★★★★ 3
Sturdy but uncomfortable
Color: Black
The seat itself is sturdy and easy to put together, I’ve now had the product for 8 months and had no issues wear/tear despite nearly daily use, but… it’s not comfy, at all. The seat cushion has a texture to it that scrapes at my legs if I don’t have an extra pillow on it or am wearing shorts. Additionally, the seat pillow is just kind of hard. It doesn’t give very much at all, so if I sit on it for more than an hour or two at a time my butt starts to get really sore. It works as a budget option, but invest in a good seat pillow if you plan to sit in it for any length of time.
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Reviewed in the United States on April 29, 2026

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